other:Article Title: Evaluation of Plant-Guided Strategies Against Clinical Multidrug-Resistant Pathogens: Preliminary Phytochemical Screening, Antioxidant Capacity, and Antibacterial/Antibiofilm Activity of Rosa canina and Colchicum autumnale Extracts
Article Snippet: S. aureus ATCC 25923 , 12.5 ± 0 f , 1.56 ± 0 d , 0.195 ± 0 b , 6.25 ± 0 e , 3125 ± 0 g , 0.78 ± 0 c , 0.0975 ± 0 a , 10 −210.
Sequencing:Article Title: Frog Skin Peptides: Nature's Dual-Action Weapons Against Infection and Cancer.
Article Snippet: .. Peptide Name and Sequence Frog Species Hydrophobic Residues (%) a 3D Structure a AC Activity AB Activity Ref. Brevinin-2R KLKNFAKGVAQSLLNKASCKL SGQC Pelophylax ridibundus 44 C-terminal Cys-bridged cyclic domain, helix BJAB (LD50 30–40 μg/mL) Jurkat (LD50 20–25 μg/mL) MCF-7 (LD50 10–15 μg/mL) A549 (n.d.) HT29 (n.d.) S. aureus 1112 (MIC 1.56 μg/mL) E. coli ATCC 2592 (MIC 0.39 μg/mL) P. aeruginosa ATCC 27853 (MIC 25 μg/mL) K. pneumoniae ATCC 13883 (MIC 12.5 μg/mL) [58,59] Caerin 1.1 GLLSVLGSVAKHVLPHVVPVIA EHL.NH2 Pengyilleyia rothii (formerly Litoria rothii); Pelodryas splendida, (formerly Litoria splendida) 56 Helix (IC50~5–13 μg/mL): B16 MCF-7 SkBr-3 TC-1 A549 (IC50 15.62 μg/mL) B-CPAP (IC50 4.038 μg/mL) CAL-62 (IC50 9.856 μg/mL) HeLa (IC50~10−9–10−8 M) S. aureus ATCC 25923 or 29213 or MRSA (MIC 1–3 μg/mL) B. cereus (MIC 50 μg/mL) * E. coli (MIC > 100 μg/mL) * L. lactis (MIC 1.5 μM) * L. innocua (MIC 25 μg/mL) * M. luteus (MIC 12 μg/mL) * E. faecalis (MIC 25 μg/mL) * S. epidermidis (MIC 12 μg/mL) * S. uberis (MIC 25 μg/mL) * E. cloacae (MIC 12 μg/mL) * P. multocida (MIC 12–25 μg/mL) * P. haemolytica (MIC 25 μg/mL) * [60–66] Caerin 1.9 GLFGVLGSIAKHVLPHVVPVIA EKL.NH2 Chlorohyla chloris (formerly Litoria chloris) 54 Helix (IC50 5–13 μg/mL): B16 B-CPAP CAL-62 HeLa MCF-7 SkBr-3 TC-1 A549 (IC50 18.52 μg/mL) TE-1 (IC50 13.00 μg/mL) U87MG (IC50 5.018 μg/mL) (Caerin 1.1 in combination with Caerin 1.9) U118MG (IC50 11.180 μg/mL) (Caerin 1.1 in combination with Caerin 1.9) S. aureus ATCC 25923 and 29213, or MRSA (MIC 3.75–12 μg/mL) M. luteus (MIC 50 μg/mL) * L. innocua (MIC 25–50 μg/mL) * S. epidermidis (MIC 25 μg/mL) * S. uberis (MIC 50 μg/mL) * B. cereus (MIC 100 μg/mL) * L. lactis (MIC 12 μg/mL) * S. hemolyticus (MIC 7.5 μg/mL) * A. baumannii (MIC 7.5 μg/mL) * E. coli (MIC 30 μg/mL) * P. aeruginosa (MIC 60 μg/mL) * [61–64,67–70] https://doi.org/10.3390/antibiotics15030324 Table 1. ..
Article Title: Frog Skin Peptides: Nature's Dual-Action Weapons Against Infection and Cancer.
Article Snippet: .. Peptide Name and Sequence Frog Species Hydrophobic Residues (%) a 3D Structure a AC Activity AB Activity Ref. Alyteserin-2a ILGKLLSTAAGLLSNL.NH2 Alytes obstetricans 56 Helix A549 (LC50 80 μM) HepG2 (LC50 85 μM) HT-29 (LC50 80 μM) MDA-MB-231 (LC50 65 μM) S. aureus ATCC 25923 (MIC 64 μM) E. coli ATCC 25726 (MIC 256 μM) K. pneumoniae ATCC 700603 (MIC 256 μM) P. aeruginosa ATCC 27853 (MIC 256 μM) A. baumannii NM8 clinical isolate (MIC 64 μM) S. maltophilia B32/4 clinical isolate (MIC 128 μM) S. epidermidis RP62A biofilm-producer (MIC 64 μM) S. epidermidis RP62A/1 biofilm non-producer variant of RP62A (MIC 32 μM) [31–33] Ascaphin-8 GFKDLLKGAAKALVKTVLF.NH2 Ascaphus truei 57 Helix HCT116 (IC50 18.83 μM) MCF-7 (IC50 9.33 μM) U87MG (IC50 9.25 μM) E. coli ATCC 25922 (MIC 6 μM) P. aeruginosa ATCC 27853 (MIC 13 μM) E. cloacae NHTCC 53001 (MIC 6 μM) K. pneumoniae KK3 9904 (MIC 6 μM) S. epidermidis RP62A biofilm producer (MIC 6 μM) Streptococcus Group B (MIC 6 μM) E. faecalis ATCC 29212 (MIC 50 μM) S. aureus NCTC 8325 (MIC 3–6 μM) MRSA USA 300 LAC (MIC 3.1 μM) E. coli K12 (MIC 12.5 μM) B. subtilis 168 (MIC 6.25 μM) P. aeruginosa PAO1 (MIC 12.5 μM) [34–36] Aurein 1.2 GLFDIIKKIAESF.NH2 Ranoidea raniformis (formerly Litoria raniformis) 53 Helix Cancer type (LC50 in M): Breast (10−5) CNS (10−5) Colon (10−5) Leukaemia (10−(4–5)) Lung (10−5) Melanoma (10−5) Ovarian (10−5) Prostate (10−5) Renal (10−5) B. cereus (MIC 100 μg/mL) * E. coli (MIC > 100 μg/mL) * L. lactis (MIC 12 μg/mL) * L. innocua (MIC 100 μg/mL) * M. luteus (MIC 100 μg/mL) * P. multocida (MIC 100 μg/mL) * S. aureus (MIC 50 μg/mL) * S. epidermidis (MIC 50 μg/mL) * S. uberis (MIC 50 μg/mL) * [37–39] Aurein 2.5 GLFDIVKKVVGAFGSL.NH2 Ranoidea aurea (formerly Litoria aurea); Ranoidea raniformis (formerly Litoria raniformis) 56 Helix Cancer type (LC50 in M): Breast (10−5) CNS (10−5) Colon (10−(4–5)) Leukaemia (10−(4–5)) Lung (10−5) Melanoma (10−(4–5)) Ovarian (10−5) Prostate (10−5) Renal (10−5) B. cereus (MIC 50 μg/mL) * E. coli (MIC > 100 μg/mL) * L. lactis (MIC 12 μg/mL) * L. innocua (MIC 50 μg/mL) * M. luteus (MIC 100 μg/mL) * P. multocida (MIC > 100 μg/mL) * S. aureus (MIC 50 μg/mL) * S. epidermidis (MIC 100 μg/mL) * S. uberis (MIC > 100 μg/mL) * [38,40] https://doi.org/10.3390/antibiotics15030324 Table 1. ..
Article Title: Frog Skin Peptides: Nature's Dual-Action Weapons Against Infection and Cancer.
Article Snippet: .. Peptide Name and Sequence Frog Species Hydrophobic Residues (%) a 3D Structure a AC Activity AB Activity Ref. Phylloseptin-PTa FLSLIPKIAGGIAALAKHL.NH2 Phyllomedusa tarsius 63 Helix H157 (LC50 6.73 μM) S. aureus NCTC 10788 (MIC 4.14 μM) MRSA NCTC 10788 (MIC 4.14 μM) E. faecalis NCTC 12697 (MIC 16.56 μM) E. coli NCTC 10418 (MIC 16.56 μM) [130] Picturin 1BN GIFKDTLKKVVAAVLTTVADNIHPK Boana boans 48 Helix A549 (IC50 30.7 μM) MDA-MB-231 (IC50 64.2 μM) HT-29 (IC50 84.9 μM) S. aureus ATCC 12600 (MIC 62.5 μM) E. coli ATCC 35218 (MIC 7.8 μM) K. pneumoniae ATCC 49472 (MIC 15.6 μM) P. aeruginosa ATCC 9072 (MIC 15.6 μM) [101] Picturin 2BN GLMDMLKKVGKVALTVAKSALLP Boana boans 57 Helix A549 (IC50 23 μM) MDA-MB-231 (IC50 26.3 μM) HT-29 (IC50 52.2 μM) S. aureus ATCC 12600 (MIC 31.3 μM) E. coli ATCC 35218 (MIC 7.8 μM) K. pneumoniae ATCC 49472 (MIC 15.6 μM) P. aeruginosa ATCC 9072 (MIC 15.6 μM) [101] Pseudhymenochirin-1Pb IKIPSFFRNILKKVGKEAVSLIAGALKQS Pseudhymenochirus merlini 48 Helix A549 (LC50 2.5 μM) MDA-MB-231 (LC50 6.6 μM) HT-29 (LC50 9.5 μM) S. aureus ATCC 25923 (MIC 5 μM) E. coli ATCC 25726 (MIC 10 μM) K. pneumoniae ATCC 700603 (MIC 20 μM) P. aeruginosa ATCC 27853 (MIC 20 μM) E. faecalis ATCC 29212 (MIC 10 μM) MRSA 127/08, 145/08, 274/08, V4180, S908, T4/6 clinical isolates (MIC 5–10 μM) A. baumannii strains NM8, NM35, NM75, NM109, NM124 clinical isolates (MIC 5–10 μM) S. maltophilia B32/1, B32/4, B5/5, B6/2, and U8708 clinical isolates (MIC 5–10 μM) S. epidermidis RP62A biofilm producer, RP62A/1 biofilm non-producer variant of RP62A, T6/19 and T37/8 clinical isolates (MIC 1.25–2.5 μM) [107,131] Pseudhymenochirin-2Pa GIFPIFAKLLGKVIKVASSLISKGRTE Pseudhymenochirus merlini 48 Helix A549 (LC50 6 μM) MDA-MB-231 (LC50 6.2 μM) HT-29 (LC50 11.5 μM) S. aureus ATCC 25923 (MIC 5 μM) E. coli ATCC 25726 (MIC > 80 μM) K. pneumoniae ATCC 700603 (MIC > 80 μM) P. aeruginosa ATCC 27853 (MIC > 80 μM) E. faecalis ATCC 29212 (MIC 20 μM) MRSA 127/08, 145/08, 274/08, V4180, S908, T4/6 clinical isolates (MIC 5–10 μM) A. baumannii strains NM8, NM35, NM75, NM109, NM124 clinical isolates (MIC 10–20 μM) S. maltophilia B32/1, B32/4, B5/5, B6/2, and U8708 clinical isolates (MIC 10–40 μM) S. epidermidis RP62A biofilm producer, RP62A/1 biofilm non-producer variant of RP62A, T6/19 and T37/8 clinical isolates (MIC 2.5–10 μM) [107,131] https://doi.org/10.3390/antibiotics15030324 Table 1. ..
Article Title: Frog Skin Peptides: Nature's Dual-Action Weapons Against Infection and Cancer.
Article Snippet: .. Peptide Name and Sequence Frog Species Hydrophobic Residues (%) a 3D Structure a AC Activity AB Activity Ref. Ocellatin-3N GIFDVLKNLAKGVITSLAS.NH2 Leptodactylus nesiotus 52 Helix A549 (LC50 35 μM) MDA-MB-231 (LC50 51 μM) HT-29 (LC50 69 μM) S. aureus ATCC 12600 (MIC 31.25 μM) S. aureus ATCC 25923 (MIC 12.5 μM) MRSA ATCC BAA2312 (MIC 31.25 μM) E. faecium ATCC 19434 (MIC 62.5 μM) E. faecalis ATCC 51299 (MIC 250 μM) S. epidermidis ATCC 12228 (MIC 6.25 μM) B. megaterium BM11 (MIC 0.78 μM) E. coli ATCC 35218 (MIC 31.25 μM) E. coli ATCC 25922 (MIC 6.25 μM) K. pneumoniae ATCC 49472 (MIC 62.5 μM) K. pneumoniae ATCC BAA2814 (MIC 62.5 μM) P. aeruginosa ATCC 27853 (MIC 25 μM) A. baumannii ATCC 19606 (MIC 6.25 μM) S. typhimurium ATCC 14028 (MIC 62.5 μM) [124,125] Palustrin-Ca GFLDIIKDTGKEFAVKILNNLKCKLAGGCPP Lithobates catesbeianus 45 Helix (BEL7402 LC50 1.375 μg/mL) HeLa (LC50 1.202 μg/mL) MGC803 (LC50 1.572 μg/mL) SGC7901 (LC50 0.951 μg/mL) SMMC7721 (LC50 1.077 μg/mL) K. pneumoniae ATCC 700603 (MIC 60 μg/mL) P. aeruginosa ATCC 227853 (MIC 30 μg/mL) L. monocytogenes ATCC 54004 (MIC 30 μg/mL) S. aureus ATCC 25923 (MIC 7.8 μg/mL) S. suis 2 CVCC 606 (MIC 31.25 μg/mL) B. subtilis ADB 403 (MIC 30 μg/mL) [126] Pentadactylin GLLDTLKGAAKNVVGSLA SKVMEKL.NH2 Leptodactylus pentadactylus, Leptodactylus labyrinthicus 48 Helix B16-F10 (IC50 25.7 μM) E. coli ATCC 25922 (MIC 25 μM) E. cloacae HNTCC 53001 (MIC 50 μM) E. faecalis ATCC 29212 (MIC 200 μM) K. pneumoniae KK3 9904 (MIC 100 μM) P. aeruginosa ATCC 27853 (MIC 100 μM) P. mirabilis ATCC 25933 (MIC > 200 μM) S. aureus NCTC 8325 (MIC 200 μM) Streptococcus Group B HNTCC 80130 (MIC 50 μM) S. epidermidis RP62A biofilm producer (MIC 100 μM) [127,128] Phylloseptin-L1 LLGMIPLAISAISALSKL.NH2 Agalychnis lemur (formerly Hylomantis lemur) 66 Helix HepG2 (LC50 35 μM) S. aureus ATCC 25923 (MIC 8 μM) [85] Phylloseptin-PHa FLSLIPAAISAVSALANHF.NH2 Pithecopus hypochondrialis (formerly Phyllomedusa hypochondrialis) 68 Helix H157 (LC50 14.10 μM) HCT116 (LD50 36.64 μM) MCF-7 (LD50 24.05 μM) MDA-MB-435S (LD50 28.48 μM) PC-3 (LD50 37.96 μM) U251MG (LD50 34.67 μM) S. aureus NCTC 10788 (MIC 32.97 μM) MRSA NCTC 12493 (MIC 32.97 μM) E. faecalis NCTC 12697 (MIC 263.78 μM) E. coli NCTC 10418 (MIC > 263.78 μM) [129,130] https://doi.org/10.3390/antibiotics15030324 Table 1. ..
Activity Assay:Article Title: Frog Skin Peptides: Nature's Dual-Action Weapons Against Infection and Cancer.
Article Snippet: .. Peptide Name and Sequence Frog Species Hydrophobic Residues (%) a 3D Structure a AC Activity AB Activity Ref. Brevinin-2R KLKNFAKGVAQSLLNKASCKL SGQC Pelophylax ridibundus 44 C-terminal Cys-bridged cyclic domain, helix BJAB (LD50 30–40 μg/mL) Jurkat (LD50 20–25 μg/mL) MCF-7 (LD50 10–15 μg/mL) A549 (n.d.) HT29 (n.d.) S. aureus 1112 (MIC 1.56 μg/mL) E. coli ATCC 2592 (MIC 0.39 μg/mL) P. aeruginosa ATCC 27853 (MIC 25 μg/mL) K. pneumoniae ATCC 13883 (MIC 12.5 μg/mL) [58,59] Caerin 1.1 GLLSVLGSVAKHVLPHVVPVIA EHL.NH2 Pengyilleyia rothii (formerly Litoria rothii); Pelodryas splendida, (formerly Litoria splendida) 56 Helix (IC50~5–13 μg/mL): B16 MCF-7 SkBr-3 TC-1 A549 (IC50 15.62 μg/mL) B-CPAP (IC50 4.038 μg/mL) CAL-62 (IC50 9.856 μg/mL) HeLa (IC50~10−9–10−8 M) S. aureus ATCC 25923 or 29213 or MRSA (MIC 1–3 μg/mL) B. cereus (MIC 50 μg/mL) * E. coli (MIC > 100 μg/mL) * L. lactis (MIC 1.5 μM) * L. innocua (MIC 25 μg/mL) * M. luteus (MIC 12 μg/mL) * E. faecalis (MIC 25 μg/mL) * S. epidermidis (MIC 12 μg/mL) * S. uberis (MIC 25 μg/mL) * E. cloacae (MIC 12 μg/mL) * P. multocida (MIC 12–25 μg/mL) * P. haemolytica (MIC 25 μg/mL) * [60–66] Caerin 1.9 GLFGVLGSIAKHVLPHVVPVIA EKL.NH2 Chlorohyla chloris (formerly Litoria chloris) 54 Helix (IC50 5–13 μg/mL): B16 B-CPAP CAL-62 HeLa MCF-7 SkBr-3 TC-1 A549 (IC50 18.52 μg/mL) TE-1 (IC50 13.00 μg/mL) U87MG (IC50 5.018 μg/mL) (Caerin 1.1 in combination with Caerin 1.9) U118MG (IC50 11.180 μg/mL) (Caerin 1.1 in combination with Caerin 1.9) S. aureus ATCC 25923 and 29213, or MRSA (MIC 3.75–12 μg/mL) M. luteus (MIC 50 μg/mL) * L. innocua (MIC 25–50 μg/mL) * S. epidermidis (MIC 25 μg/mL) * S. uberis (MIC 50 μg/mL) * B. cereus (MIC 100 μg/mL) * L. lactis (MIC 12 μg/mL) * S. hemolyticus (MIC 7.5 μg/mL) * A. baumannii (MIC 7.5 μg/mL) * E. coli (MIC 30 μg/mL) * P. aeruginosa (MIC 60 μg/mL) * [61–64,67–70] https://doi.org/10.3390/antibiotics15030324 Table 1. ..
Article Title: Frog Skin Peptides: Nature's Dual-Action Weapons Against Infection and Cancer.
Article Snippet: .. Peptide Name and Sequence Frog Species Hydrophobic Residues (%) a 3D Structure a AC Activity AB Activity Ref. Alyteserin-2a ILGKLLSTAAGLLSNL.NH2 Alytes obstetricans 56 Helix A549 (LC50 80 μM) HepG2 (LC50 85 μM) HT-29 (LC50 80 μM) MDA-MB-231 (LC50 65 μM) S. aureus ATCC 25923 (MIC 64 μM) E. coli ATCC 25726 (MIC 256 μM) K. pneumoniae ATCC 700603 (MIC 256 μM) P. aeruginosa ATCC 27853 (MIC 256 μM) A. baumannii NM8 clinical isolate (MIC 64 μM) S. maltophilia B32/4 clinical isolate (MIC 128 μM) S. epidermidis RP62A biofilm-producer (MIC 64 μM) S. epidermidis RP62A/1 biofilm non-producer variant of RP62A (MIC 32 μM) [31–33] Ascaphin-8 GFKDLLKGAAKALVKTVLF.NH2 Ascaphus truei 57 Helix HCT116 (IC50 18.83 μM) MCF-7 (IC50 9.33 μM) U87MG (IC50 9.25 μM) E. coli ATCC 25922 (MIC 6 μM) P. aeruginosa ATCC 27853 (MIC 13 μM) E. cloacae NHTCC 53001 (MIC 6 μM) K. pneumoniae KK3 9904 (MIC 6 μM) S. epidermidis RP62A biofilm producer (MIC 6 μM) Streptococcus Group B (MIC 6 μM) E. faecalis ATCC 29212 (MIC 50 μM) S. aureus NCTC 8325 (MIC 3–6 μM) MRSA USA 300 LAC (MIC 3.1 μM) E. coli K12 (MIC 12.5 μM) B. subtilis 168 (MIC 6.25 μM) P. aeruginosa PAO1 (MIC 12.5 μM) [34–36] Aurein 1.2 GLFDIIKKIAESF.NH2 Ranoidea raniformis (formerly Litoria raniformis) 53 Helix Cancer type (LC50 in M): Breast (10−5) CNS (10−5) Colon (10−5) Leukaemia (10−(4–5)) Lung (10−5) Melanoma (10−5) Ovarian (10−5) Prostate (10−5) Renal (10−5) B. cereus (MIC 100 μg/mL) * E. coli (MIC > 100 μg/mL) * L. lactis (MIC 12 μg/mL) * L. innocua (MIC 100 μg/mL) * M. luteus (MIC 100 μg/mL) * P. multocida (MIC 100 μg/mL) * S. aureus (MIC 50 μg/mL) * S. epidermidis (MIC 50 μg/mL) * S. uberis (MIC 50 μg/mL) * [37–39] Aurein 2.5 GLFDIVKKVVGAFGSL.NH2 Ranoidea aurea (formerly Litoria aurea); Ranoidea raniformis (formerly Litoria raniformis) 56 Helix Cancer type (LC50 in M): Breast (10−5) CNS (10−5) Colon (10−(4–5)) Leukaemia (10−(4–5)) Lung (10−5) Melanoma (10−(4–5)) Ovarian (10−5) Prostate (10−5) Renal (10−5) B. cereus (MIC 50 μg/mL) * E. coli (MIC > 100 μg/mL) * L. lactis (MIC 12 μg/mL) * L. innocua (MIC 50 μg/mL) * M. luteus (MIC 100 μg/mL) * P. multocida (MIC > 100 μg/mL) * S. aureus (MIC 50 μg/mL) * S. epidermidis (MIC 100 μg/mL) * S. uberis (MIC > 100 μg/mL) * [38,40] https://doi.org/10.3390/antibiotics15030324 Table 1. ..
Article Title: Frog Skin Peptides: Nature's Dual-Action Weapons Against Infection and Cancer.
Article Snippet: .. Peptide Name and Sequence Frog Species Hydrophobic Residues (%) a 3D Structure a AC Activity AB Activity Ref. Phylloseptin-PTa FLSLIPKIAGGIAALAKHL.NH2 Phyllomedusa tarsius 63 Helix H157 (LC50 6.73 μM) S. aureus NCTC 10788 (MIC 4.14 μM) MRSA NCTC 10788 (MIC 4.14 μM) E. faecalis NCTC 12697 (MIC 16.56 μM) E. coli NCTC 10418 (MIC 16.56 μM) [130] Picturin 1BN GIFKDTLKKVVAAVLTTVADNIHPK Boana boans 48 Helix A549 (IC50 30.7 μM) MDA-MB-231 (IC50 64.2 μM) HT-29 (IC50 84.9 μM) S. aureus ATCC 12600 (MIC 62.5 μM) E. coli ATCC 35218 (MIC 7.8 μM) K. pneumoniae ATCC 49472 (MIC 15.6 μM) P. aeruginosa ATCC 9072 (MIC 15.6 μM) [101] Picturin 2BN GLMDMLKKVGKVALTVAKSALLP Boana boans 57 Helix A549 (IC50 23 μM) MDA-MB-231 (IC50 26.3 μM) HT-29 (IC50 52.2 μM) S. aureus ATCC 12600 (MIC 31.3 μM) E. coli ATCC 35218 (MIC 7.8 μM) K. pneumoniae ATCC 49472 (MIC 15.6 μM) P. aeruginosa ATCC 9072 (MIC 15.6 μM) [101] Pseudhymenochirin-1Pb IKIPSFFRNILKKVGKEAVSLIAGALKQS Pseudhymenochirus merlini 48 Helix A549 (LC50 2.5 μM) MDA-MB-231 (LC50 6.6 μM) HT-29 (LC50 9.5 μM) S. aureus ATCC 25923 (MIC 5 μM) E. coli ATCC 25726 (MIC 10 μM) K. pneumoniae ATCC 700603 (MIC 20 μM) P. aeruginosa ATCC 27853 (MIC 20 μM) E. faecalis ATCC 29212 (MIC 10 μM) MRSA 127/08, 145/08, 274/08, V4180, S908, T4/6 clinical isolates (MIC 5–10 μM) A. baumannii strains NM8, NM35, NM75, NM109, NM124 clinical isolates (MIC 5–10 μM) S. maltophilia B32/1, B32/4, B5/5, B6/2, and U8708 clinical isolates (MIC 5–10 μM) S. epidermidis RP62A biofilm producer, RP62A/1 biofilm non-producer variant of RP62A, T6/19 and T37/8 clinical isolates (MIC 1.25–2.5 μM) [107,131] Pseudhymenochirin-2Pa GIFPIFAKLLGKVIKVASSLISKGRTE Pseudhymenochirus merlini 48 Helix A549 (LC50 6 μM) MDA-MB-231 (LC50 6.2 μM) HT-29 (LC50 11.5 μM) S. aureus ATCC 25923 (MIC 5 μM) E. coli ATCC 25726 (MIC > 80 μM) K. pneumoniae ATCC 700603 (MIC > 80 μM) P. aeruginosa ATCC 27853 (MIC > 80 μM) E. faecalis ATCC 29212 (MIC 20 μM) MRSA 127/08, 145/08, 274/08, V4180, S908, T4/6 clinical isolates (MIC 5–10 μM) A. baumannii strains NM8, NM35, NM75, NM109, NM124 clinical isolates (MIC 10–20 μM) S. maltophilia B32/1, B32/4, B5/5, B6/2, and U8708 clinical isolates (MIC 10–40 μM) S. epidermidis RP62A biofilm producer, RP62A/1 biofilm non-producer variant of RP62A, T6/19 and T37/8 clinical isolates (MIC 2.5–10 μM) [107,131] https://doi.org/10.3390/antibiotics15030324 Table 1. ..
Article Title: Frog Skin Peptides: Nature's Dual-Action Weapons Against Infection and Cancer.
Article Snippet: .. Peptide Name and Sequence Frog Species Hydrophobic Residues (%) a 3D Structure a AC Activity AB Activity Ref. Ocellatin-3N GIFDVLKNLAKGVITSLAS.NH2 Leptodactylus nesiotus 52 Helix A549 (LC50 35 μM) MDA-MB-231 (LC50 51 μM) HT-29 (LC50 69 μM) S. aureus ATCC 12600 (MIC 31.25 μM) S. aureus ATCC 25923 (MIC 12.5 μM) MRSA ATCC BAA2312 (MIC 31.25 μM) E. faecium ATCC 19434 (MIC 62.5 μM) E. faecalis ATCC 51299 (MIC 250 μM) S. epidermidis ATCC 12228 (MIC 6.25 μM) B. megaterium BM11 (MIC 0.78 μM) E. coli ATCC 35218 (MIC 31.25 μM) E. coli ATCC 25922 (MIC 6.25 μM) K. pneumoniae ATCC 49472 (MIC 62.5 μM) K. pneumoniae ATCC BAA2814 (MIC 62.5 μM) P. aeruginosa ATCC 27853 (MIC 25 μM) A. baumannii ATCC 19606 (MIC 6.25 μM) S. typhimurium ATCC 14028 (MIC 62.5 μM) [124,125] Palustrin-Ca GFLDIIKDTGKEFAVKILNNLKCKLAGGCPP Lithobates catesbeianus 45 Helix (BEL7402 LC50 1.375 μg/mL) HeLa (LC50 1.202 μg/mL) MGC803 (LC50 1.572 μg/mL) SGC7901 (LC50 0.951 μg/mL) SMMC7721 (LC50 1.077 μg/mL) K. pneumoniae ATCC 700603 (MIC 60 μg/mL) P. aeruginosa ATCC 227853 (MIC 30 μg/mL) L. monocytogenes ATCC 54004 (MIC 30 μg/mL) S. aureus ATCC 25923 (MIC 7.8 μg/mL) S. suis 2 CVCC 606 (MIC 31.25 μg/mL) B. subtilis ADB 403 (MIC 30 μg/mL) [126] Pentadactylin GLLDTLKGAAKNVVGSLA SKVMEKL.NH2 Leptodactylus pentadactylus, Leptodactylus labyrinthicus 48 Helix B16-F10 (IC50 25.7 μM) E. coli ATCC 25922 (MIC 25 μM) E. cloacae HNTCC 53001 (MIC 50 μM) E. faecalis ATCC 29212 (MIC 200 μM) K. pneumoniae KK3 9904 (MIC 100 μM) P. aeruginosa ATCC 27853 (MIC 100 μM) P. mirabilis ATCC 25933 (MIC > 200 μM) S. aureus NCTC 8325 (MIC 200 μM) Streptococcus Group B HNTCC 80130 (MIC 50 μM) S. epidermidis RP62A biofilm producer (MIC 100 μM) [127,128] Phylloseptin-L1 LLGMIPLAISAISALSKL.NH2 Agalychnis lemur (formerly Hylomantis lemur) 66 Helix HepG2 (LC50 35 μM) S. aureus ATCC 25923 (MIC 8 μM) [85] Phylloseptin-PHa FLSLIPAAISAVSALANHF.NH2 Pithecopus hypochondrialis (formerly Phyllomedusa hypochondrialis) 68 Helix H157 (LC50 14.10 μM) HCT116 (LD50 36.64 μM) MCF-7 (LD50 24.05 μM) MDA-MB-435S (LD50 28.48 μM) PC-3 (LD50 37.96 μM) U251MG (LD50 34.67 μM) S. aureus NCTC 10788 (MIC 32.97 μM) MRSA NCTC 12493 (MIC 32.97 μM) E. faecalis NCTC 12697 (MIC 263.78 μM) E. coli NCTC 10418 (MIC > 263.78 μM) [129,130] https://doi.org/10.3390/antibiotics15030324 Table 1. ..
Control:
Multiple Displacement Amplification:Article Title: Frog Skin Peptides: Nature's Dual-Action Weapons Against Infection and Cancer.
Article Snippet: .. Peptide Name and Sequence Frog Species Hydrophobic Residues (%) a 3D Structure a AC Activity AB Activity Ref. Alyteserin-2a ILGKLLSTAAGLLSNL.NH2 Alytes obstetricans 56 Helix A549 (LC50 80 μM) HepG2 (LC50 85 μM) HT-29 (LC50 80 μM) MDA-MB-231 (LC50 65 μM) S. aureus ATCC 25923 (MIC 64 μM) E. coli ATCC 25726 (MIC 256 μM) K. pneumoniae ATCC 700603 (MIC 256 μM) P. aeruginosa ATCC 27853 (MIC 256 μM) A. baumannii NM8 clinical isolate (MIC 64 μM) S. maltophilia B32/4 clinical isolate (MIC 128 μM) S. epidermidis RP62A biofilm-producer (MIC 64 μM) S. epidermidis RP62A/1 biofilm non-producer variant of RP62A (MIC 32 μM) [31–33] Ascaphin-8 GFKDLLKGAAKALVKTVLF.NH2 Ascaphus truei 57 Helix HCT116 (IC50 18.83 μM) MCF-7 (IC50 9.33 μM) U87MG (IC50 9.25 μM) E. coli ATCC 25922 (MIC 6 μM) P. aeruginosa ATCC 27853 (MIC 13 μM) E. cloacae NHTCC 53001 (MIC 6 μM) K. pneumoniae KK3 9904 (MIC 6 μM) S. epidermidis RP62A biofilm producer (MIC 6 μM) Streptococcus Group B (MIC 6 μM) E. faecalis ATCC 29212 (MIC 50 μM) S. aureus NCTC 8325 (MIC 3–6 μM) MRSA USA 300 LAC (MIC 3.1 μM) E. coli K12 (MIC 12.5 μM) B. subtilis 168 (MIC 6.25 μM) P. aeruginosa PAO1 (MIC 12.5 μM) [34–36] Aurein 1.2 GLFDIIKKIAESF.NH2 Ranoidea raniformis (formerly Litoria raniformis) 53 Helix Cancer type (LC50 in M): Breast (10−5) CNS (10−5) Colon (10−5) Leukaemia (10−(4–5)) Lung (10−5) Melanoma (10−5) Ovarian (10−5) Prostate (10−5) Renal (10−5) B. cereus (MIC 100 μg/mL) * E. coli (MIC > 100 μg/mL) * L. lactis (MIC 12 μg/mL) * L. innocua (MIC 100 μg/mL) * M. luteus (MIC 100 μg/mL) * P. multocida (MIC 100 μg/mL) * S. aureus (MIC 50 μg/mL) * S. epidermidis (MIC 50 μg/mL) * S. uberis (MIC 50 μg/mL) * [37–39] Aurein 2.5 GLFDIVKKVVGAFGSL.NH2 Ranoidea aurea (formerly Litoria aurea); Ranoidea raniformis (formerly Litoria raniformis) 56 Helix Cancer type (LC50 in M): Breast (10−5) CNS (10−5) Colon (10−(4–5)) Leukaemia (10−(4–5)) Lung (10−5) Melanoma (10−(4–5)) Ovarian (10−5) Prostate (10−5) Renal (10−5) B. cereus (MIC 50 μg/mL) * E. coli (MIC > 100 μg/mL) * L. lactis (MIC 12 μg/mL) * L. innocua (MIC 50 μg/mL) * M. luteus (MIC 100 μg/mL) * P. multocida (MIC > 100 μg/mL) * S. aureus (MIC 50 μg/mL) * S. epidermidis (MIC 100 μg/mL) * S. uberis (MIC > 100 μg/mL) * [38,40] https://doi.org/10.3390/antibiotics15030324 Table 1. ..
Article Title: Frog Skin Peptides: Nature's Dual-Action Weapons Against Infection and Cancer.
Article Snippet: .. Peptide Name and Sequence Frog Species Hydrophobic Residues (%) a 3D Structure a AC Activity AB Activity Ref. Phylloseptin-PTa FLSLIPKIAGGIAALAKHL.NH2 Phyllomedusa tarsius 63 Helix H157 (LC50 6.73 μM) S. aureus NCTC 10788 (MIC 4.14 μM) MRSA NCTC 10788 (MIC 4.14 μM) E. faecalis NCTC 12697 (MIC 16.56 μM) E. coli NCTC 10418 (MIC 16.56 μM) [130] Picturin 1BN GIFKDTLKKVVAAVLTTVADNIHPK Boana boans 48 Helix A549 (IC50 30.7 μM) MDA-MB-231 (IC50 64.2 μM) HT-29 (IC50 84.9 μM) S. aureus ATCC 12600 (MIC 62.5 μM) E. coli ATCC 35218 (MIC 7.8 μM) K. pneumoniae ATCC 49472 (MIC 15.6 μM) P. aeruginosa ATCC 9072 (MIC 15.6 μM) [101] Picturin 2BN GLMDMLKKVGKVALTVAKSALLP Boana boans 57 Helix A549 (IC50 23 μM) MDA-MB-231 (IC50 26.3 μM) HT-29 (IC50 52.2 μM) S. aureus ATCC 12600 (MIC 31.3 μM) E. coli ATCC 35218 (MIC 7.8 μM) K. pneumoniae ATCC 49472 (MIC 15.6 μM) P. aeruginosa ATCC 9072 (MIC 15.6 μM) [101] Pseudhymenochirin-1Pb IKIPSFFRNILKKVGKEAVSLIAGALKQS Pseudhymenochirus merlini 48 Helix A549 (LC50 2.5 μM) MDA-MB-231 (LC50 6.6 μM) HT-29 (LC50 9.5 μM) S. aureus ATCC 25923 (MIC 5 μM) E. coli ATCC 25726 (MIC 10 μM) K. pneumoniae ATCC 700603 (MIC 20 μM) P. aeruginosa ATCC 27853 (MIC 20 μM) E. faecalis ATCC 29212 (MIC 10 μM) MRSA 127/08, 145/08, 274/08, V4180, S908, T4/6 clinical isolates (MIC 5–10 μM) A. baumannii strains NM8, NM35, NM75, NM109, NM124 clinical isolates (MIC 5–10 μM) S. maltophilia B32/1, B32/4, B5/5, B6/2, and U8708 clinical isolates (MIC 5–10 μM) S. epidermidis RP62A biofilm producer, RP62A/1 biofilm non-producer variant of RP62A, T6/19 and T37/8 clinical isolates (MIC 1.25–2.5 μM) [107,131] Pseudhymenochirin-2Pa GIFPIFAKLLGKVIKVASSLISKGRTE Pseudhymenochirus merlini 48 Helix A549 (LC50 6 μM) MDA-MB-231 (LC50 6.2 μM) HT-29 (LC50 11.5 μM) S. aureus ATCC 25923 (MIC 5 μM) E. coli ATCC 25726 (MIC > 80 μM) K. pneumoniae ATCC 700603 (MIC > 80 μM) P. aeruginosa ATCC 27853 (MIC > 80 μM) E. faecalis ATCC 29212 (MIC 20 μM) MRSA 127/08, 145/08, 274/08, V4180, S908, T4/6 clinical isolates (MIC 5–10 μM) A. baumannii strains NM8, NM35, NM75, NM109, NM124 clinical isolates (MIC 10–20 μM) S. maltophilia B32/1, B32/4, B5/5, B6/2, and U8708 clinical isolates (MIC 10–40 μM) S. epidermidis RP62A biofilm producer, RP62A/1 biofilm non-producer variant of RP62A, T6/19 and T37/8 clinical isolates (MIC 2.5–10 μM) [107,131] https://doi.org/10.3390/antibiotics15030324 Table 1. ..
Article Title: Frog Skin Peptides: Nature's Dual-Action Weapons Against Infection and Cancer.
Article Snippet: .. Peptide Name and Sequence Frog Species Hydrophobic Residues (%) a 3D Structure a AC Activity AB Activity Ref. Ocellatin-3N GIFDVLKNLAKGVITSLAS.NH2 Leptodactylus nesiotus 52 Helix A549 (LC50 35 μM) MDA-MB-231 (LC50 51 μM) HT-29 (LC50 69 μM) S. aureus ATCC 12600 (MIC 31.25 μM) S. aureus ATCC 25923 (MIC 12.5 μM) MRSA ATCC BAA2312 (MIC 31.25 μM) E. faecium ATCC 19434 (MIC 62.5 μM) E. faecalis ATCC 51299 (MIC 250 μM) S. epidermidis ATCC 12228 (MIC 6.25 μM) B. megaterium BM11 (MIC 0.78 μM) E. coli ATCC 35218 (MIC 31.25 μM) E. coli ATCC 25922 (MIC 6.25 μM) K. pneumoniae ATCC 49472 (MIC 62.5 μM) K. pneumoniae ATCC BAA2814 (MIC 62.5 μM) P. aeruginosa ATCC 27853 (MIC 25 μM) A. baumannii ATCC 19606 (MIC 6.25 μM) S. typhimurium ATCC 14028 (MIC 62.5 μM) [124,125] Palustrin-Ca GFLDIIKDTGKEFAVKILNNLKCKLAGGCPP Lithobates catesbeianus 45 Helix (BEL7402 LC50 1.375 μg/mL) HeLa (LC50 1.202 μg/mL) MGC803 (LC50 1.572 μg/mL) SGC7901 (LC50 0.951 μg/mL) SMMC7721 (LC50 1.077 μg/mL) K. pneumoniae ATCC 700603 (MIC 60 μg/mL) P. aeruginosa ATCC 227853 (MIC 30 μg/mL) L. monocytogenes ATCC 54004 (MIC 30 μg/mL) S. aureus ATCC 25923 (MIC 7.8 μg/mL) S. suis 2 CVCC 606 (MIC 31.25 μg/mL) B. subtilis ADB 403 (MIC 30 μg/mL) [126] Pentadactylin GLLDTLKGAAKNVVGSLA SKVMEKL.NH2 Leptodactylus pentadactylus, Leptodactylus labyrinthicus 48 Helix B16-F10 (IC50 25.7 μM) E. coli ATCC 25922 (MIC 25 μM) E. cloacae HNTCC 53001 (MIC 50 μM) E. faecalis ATCC 29212 (MIC 200 μM) K. pneumoniae KK3 9904 (MIC 100 μM) P. aeruginosa ATCC 27853 (MIC 100 μM) P. mirabilis ATCC 25933 (MIC > 200 μM) S. aureus NCTC 8325 (MIC 200 μM) Streptococcus Group B HNTCC 80130 (MIC 50 μM) S. epidermidis RP62A biofilm producer (MIC 100 μM) [127,128] Phylloseptin-L1 LLGMIPLAISAISALSKL.NH2 Agalychnis lemur (formerly Hylomantis lemur) 66 Helix HepG2 (LC50 35 μM) S. aureus ATCC 25923 (MIC 8 μM) [85] Phylloseptin-PHa FLSLIPAAISAVSALANHF.NH2 Pithecopus hypochondrialis (formerly Phyllomedusa hypochondrialis) 68 Helix H157 (LC50 14.10 μM) HCT116 (LD50 36.64 μM) MCF-7 (LD50 24.05 μM) MDA-MB-435S (LD50 28.48 μM) PC-3 (LD50 37.96 μM) U251MG (LD50 34.67 μM) S. aureus NCTC 10788 (MIC 32.97 μM) MRSA NCTC 12493 (MIC 32.97 μM) E. faecalis NCTC 12697 (MIC 263.78 μM) E. coli NCTC 10418 (MIC > 263.78 μM) [129,130] https://doi.org/10.3390/antibiotics15030324 Table 1. ..
Variant Assay:Article Title: Frog Skin Peptides: Nature's Dual-Action Weapons Against Infection and Cancer.
Article Snippet: .. Peptide Name and Sequence Frog Species Hydrophobic Residues (%) a 3D Structure a AC Activity AB Activity Ref. Alyteserin-2a ILGKLLSTAAGLLSNL.NH2 Alytes obstetricans 56 Helix A549 (LC50 80 μM) HepG2 (LC50 85 μM) HT-29 (LC50 80 μM) MDA-MB-231 (LC50 65 μM) S. aureus ATCC 25923 (MIC 64 μM) E. coli ATCC 25726 (MIC 256 μM) K. pneumoniae ATCC 700603 (MIC 256 μM) P. aeruginosa ATCC 27853 (MIC 256 μM) A. baumannii NM8 clinical isolate (MIC 64 μM) S. maltophilia B32/4 clinical isolate (MIC 128 μM) S. epidermidis RP62A biofilm-producer (MIC 64 μM) S. epidermidis RP62A/1 biofilm non-producer variant of RP62A (MIC 32 μM) [31–33] Ascaphin-8 GFKDLLKGAAKALVKTVLF.NH2 Ascaphus truei 57 Helix HCT116 (IC50 18.83 μM) MCF-7 (IC50 9.33 μM) U87MG (IC50 9.25 μM) E. coli ATCC 25922 (MIC 6 μM) P. aeruginosa ATCC 27853 (MIC 13 μM) E. cloacae NHTCC 53001 (MIC 6 μM) K. pneumoniae KK3 9904 (MIC 6 μM) S. epidermidis RP62A biofilm producer (MIC 6 μM) Streptococcus Group B (MIC 6 μM) E. faecalis ATCC 29212 (MIC 50 μM) S. aureus NCTC 8325 (MIC 3–6 μM) MRSA USA 300 LAC (MIC 3.1 μM) E. coli K12 (MIC 12.5 μM) B. subtilis 168 (MIC 6.25 μM) P. aeruginosa PAO1 (MIC 12.5 μM) [34–36] Aurein 1.2 GLFDIIKKIAESF.NH2 Ranoidea raniformis (formerly Litoria raniformis) 53 Helix Cancer type (LC50 in M): Breast (10−5) CNS (10−5) Colon (10−5) Leukaemia (10−(4–5)) Lung (10−5) Melanoma (10−5) Ovarian (10−5) Prostate (10−5) Renal (10−5) B. cereus (MIC 100 μg/mL) * E. coli (MIC > 100 μg/mL) * L. lactis (MIC 12 μg/mL) * L. innocua (MIC 100 μg/mL) * M. luteus (MIC 100 μg/mL) * P. multocida (MIC 100 μg/mL) * S. aureus (MIC 50 μg/mL) * S. epidermidis (MIC 50 μg/mL) * S. uberis (MIC 50 μg/mL) * [37–39] Aurein 2.5 GLFDIVKKVVGAFGSL.NH2 Ranoidea aurea (formerly Litoria aurea); Ranoidea raniformis (formerly Litoria raniformis) 56 Helix Cancer type (LC50 in M): Breast (10−5) CNS (10−5) Colon (10−(4–5)) Leukaemia (10−(4–5)) Lung (10−5) Melanoma (10−(4–5)) Ovarian (10−5) Prostate (10−5) Renal (10−5) B. cereus (MIC 50 μg/mL) * E. coli (MIC > 100 μg/mL) * L. lactis (MIC 12 μg/mL) * L. innocua (MIC 50 μg/mL) * M. luteus (MIC 100 μg/mL) * P. multocida (MIC > 100 μg/mL) * S. aureus (MIC 50 μg/mL) * S. epidermidis (MIC 100 μg/mL) * S. uberis (MIC > 100 μg/mL) * [38,40] https://doi.org/10.3390/antibiotics15030324 Table 1. ..
Article Title: Frog Skin Peptides: Nature's Dual-Action Weapons Against Infection and Cancer.
Article Snippet: .. Peptide Name and Sequence Frog Species Hydrophobic Residues (%) a 3D Structure a AC Activity AB Activity Ref. Phylloseptin-PTa FLSLIPKIAGGIAALAKHL.NH2 Phyllomedusa tarsius 63 Helix H157 (LC50 6.73 μM) S. aureus NCTC 10788 (MIC 4.14 μM) MRSA NCTC 10788 (MIC 4.14 μM) E. faecalis NCTC 12697 (MIC 16.56 μM) E. coli NCTC 10418 (MIC 16.56 μM) [130] Picturin 1BN GIFKDTLKKVVAAVLTTVADNIHPK Boana boans 48 Helix A549 (IC50 30.7 μM) MDA-MB-231 (IC50 64.2 μM) HT-29 (IC50 84.9 μM) S. aureus ATCC 12600 (MIC 62.5 μM) E. coli ATCC 35218 (MIC 7.8 μM) K. pneumoniae ATCC 49472 (MIC 15.6 μM) P. aeruginosa ATCC 9072 (MIC 15.6 μM) [101] Picturin 2BN GLMDMLKKVGKVALTVAKSALLP Boana boans 57 Helix A549 (IC50 23 μM) MDA-MB-231 (IC50 26.3 μM) HT-29 (IC50 52.2 μM) S. aureus ATCC 12600 (MIC 31.3 μM) E. coli ATCC 35218 (MIC 7.8 μM) K. pneumoniae ATCC 49472 (MIC 15.6 μM) P. aeruginosa ATCC 9072 (MIC 15.6 μM) [101] Pseudhymenochirin-1Pb IKIPSFFRNILKKVGKEAVSLIAGALKQS Pseudhymenochirus merlini 48 Helix A549 (LC50 2.5 μM) MDA-MB-231 (LC50 6.6 μM) HT-29 (LC50 9.5 μM) S. aureus ATCC 25923 (MIC 5 μM) E. coli ATCC 25726 (MIC 10 μM) K. pneumoniae ATCC 700603 (MIC 20 μM) P. aeruginosa ATCC 27853 (MIC 20 μM) E. faecalis ATCC 29212 (MIC 10 μM) MRSA 127/08, 145/08, 274/08, V4180, S908, T4/6 clinical isolates (MIC 5–10 μM) A. baumannii strains NM8, NM35, NM75, NM109, NM124 clinical isolates (MIC 5–10 μM) S. maltophilia B32/1, B32/4, B5/5, B6/2, and U8708 clinical isolates (MIC 5–10 μM) S. epidermidis RP62A biofilm producer, RP62A/1 biofilm non-producer variant of RP62A, T6/19 and T37/8 clinical isolates (MIC 1.25–2.5 μM) [107,131] Pseudhymenochirin-2Pa GIFPIFAKLLGKVIKVASSLISKGRTE Pseudhymenochirus merlini 48 Helix A549 (LC50 6 μM) MDA-MB-231 (LC50 6.2 μM) HT-29 (LC50 11.5 μM) S. aureus ATCC 25923 (MIC 5 μM) E. coli ATCC 25726 (MIC > 80 μM) K. pneumoniae ATCC 700603 (MIC > 80 μM) P. aeruginosa ATCC 27853 (MIC > 80 μM) E. faecalis ATCC 29212 (MIC 20 μM) MRSA 127/08, 145/08, 274/08, V4180, S908, T4/6 clinical isolates (MIC 5–10 μM) A. baumannii strains NM8, NM35, NM75, NM109, NM124 clinical isolates (MIC 10–20 μM) S. maltophilia B32/1, B32/4, B5/5, B6/2, and U8708 clinical isolates (MIC 10–40 μM) S. epidermidis RP62A biofilm producer, RP62A/1 biofilm non-producer variant of RP62A, T6/19 and T37/8 clinical isolates (MIC 2.5–10 μM) [107,131] https://doi.org/10.3390/antibiotics15030324 Table 1. ..
Suspension:
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